MOLECULAR & CELL BIOLOGY
Molecular and cell biology expertise
Molecular and cell biology expertise
Molecular and cell biology expertise
Explore our scientific capabilities in gene editing, molecular engineering, custom assays, cell analysis, sequencing and bioinformatics. Based in Copenhagen, Denmark, we select methods to address your biological question and provide the evidence your project needs.
Explore our scientific capabilities in gene editing, molecular engineering, custom assays, cell analysis, sequencing and bioinformatics. Based in Copenhagen, Denmark, we select methods to address your biological question and provide the evidence your project needs.
01
Gene editing and genomic medicine
• Unbiased off-target assessment and orthogonal validation for gene editing programs • On-target efficacy profiling using quantitative assays to measure editing outcomes and functional impact • Comparative platform evaluation to support the selection of nucleases, base editors or other editing architectures • Analytical workflows and reporting aligned with development-stage decisions and IND-enabling needs • Assay development and experimental support for emerging gene editing technologies, including new editor classes and recombinase-based systems
• Unbiased off-target assessment and orthogonal validation for gene editing programs • On-target efficacy profiling using quantitative assays to measure editing outcomes and functional impact • Comparative platform evaluation to support the selection of nucleases, base editors or other editing architectures • Analytical workflows and reporting aligned with development-stage decisions and IND-enabling needs • Assay development and experimental support for emerging gene editing technologies, including new editor classes and recombinase-based systems
02
Molecular biology and engineering
• Advanced DNA cloning, mutagenesis, and knock-in and knock-out strategies • Custom plasmid design, in vitro transcription (IVT), and RNA synthesis (mRNA, circRNA and ncRNA) • Lentiviral and retroviral transduction for complex experiments
• Advanced DNA cloning, mutagenesis, and knock-in and knock-out strategies • Custom plasmid design, in vitro transcription (IVT), and RNA synthesis (mRNA, circRNA and ncRNA) • Lentiviral and retroviral transduction for complex experiments
03
Protein and assay discovery
• Recombinant protein production in bacterial and insect systems • Development and optimization of custom immunoassays, enzymatic assays, and ELISA and AlphaLISA platforms • High-content and high-throughput screening with automated liquid handling
• Recombinant protein production in bacterial and insect systems • Development and optimization of custom immunoassays, enzymatic assays, and ELISA and AlphaLISA platforms • High-content and high-throughput screening with automated liquid handling
04
Cell biology and analysis
• Expertise in cell culture, transfection, transduction and electroporation • Assays for cell proliferation, viability, apoptosis, invasion and phenotype • Cell sorting, differentiation and subcellular fractionation
• Expertise in cell culture, transfection, transduction and electroporation • Assays for cell proliferation, viability, apoptosis, invasion and phenotype • Cell sorting, differentiation and subcellular fractionation
05
Biomarker and target validation
• Custom assays for monitoring drug response and studying mode of action • CRISPR-based genetic screening, drug resistance models and genetic complementation • Advanced analyses of phenotype, transcription, replication and translation
• Custom assays for monitoring drug response and studying mode of action • CRISPR-based genetic screening, drug resistance models and genetic complementation • Advanced analyses of phenotype, transcription, replication and translation
06
Proteomics and molecular interactions
• Protein purification, characterization and drug-target engagement (NanoBRET, TSA, CETSA and MST) • Identification of drug-interacting proteins and their complex partners
• Protein purification, characterization and drug-target engagement (NanoBRET, TSA, CETSA and MST) • Identification of drug-interacting proteins and their complex partners
07
Cell line engineering
• Disease model development using CRISPR, RNAi and overexpression • Generation and functional analysis of isogenic cell pairs for drug screening and disease modeling
• Disease model development using CRISPR, RNAi and overexpression • Generation and functional analysis of isogenic cell pairs for drug screening and disease modeling
08
Next-generation sequencing (NGS) and omics
• End-to-end NGS workflows: RNA/DNA isolation, library preparation and sequencing (WGS, exome, RNA-seq, ChIP-seq, ATAC-seq and more) • Epigenomics, transcriptomics and CRISPR gene editing analysis
• End-to-end NGS workflows: RNA/DNA isolation, library preparation and sequencing (WGS, exome, RNA-seq, ChIP-seq, ATAC-seq and more) • Epigenomics, transcriptomics and CRISPR gene editing analysis
09
Bioinformatics and data analysis
• Custom multi-omics data analysis pipelines and advanced computational solutions • Database mining and development of user-friendly software tools
• Custom multi-omics data analysis pipelines and advanced computational solutions • Database mining and development of user-friendly software tools
Let’s work together
Tell us what you need help with. We’ll reply within 1–2 working days to discuss the next steps.
Tell us what you need help with. We’ll reply within 1–2 working days to discuss the next steps.